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These studies established an excellent safety and tolerability profile, with no serious adverse events attributed to the compound

These findings suggest a wide safety margin, though absence of long-term human data represents a significant gap

Whilst these compounds have established biochemical functions, there is no robust randomised controlled trial evidence for clinically meaningful weight loss or fat reduction in replete individuals

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The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings