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Beyond telomere biology, Epithalon has demonstrated antioxidant properties by upregulating superoxide dismutase (SOD) and glutathione peroxidase expression
Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome cRelease
R.RutmanA.SmithS.et al (1993)
In contrast to necroptosis, the defining event in the mitochondria-mediated necrosis is the opening of the mitochondrial permeability transition pore (mPTP) on the inner mitochondrial membrane regulated by cyclophilin D (CypD) and/or increased outer mitochondrial membrane permeability mediated by Bax and Bak 7, 8
JAMA Internal Medicine
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