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Patients should not inject research-use or online products marketed as retatrutide

The medication enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, delays gastric emptying, and reduces appetite through central mechanisms

Code availability The R script used for the analyses in this study has been deposited on GitHub and can be accessed at the following link: The code is publicly available and can be reused without restriction

The discounted GLP-1 net price for state Medicaid programs will be available through additional supplemental rebates (on top of statutory rebates through the MDRP)

Instead, it should encourage a more mature plan: physician follow-up, realistic expectations, muscle preservation, nutrition support, and long-term metabolic monitoring