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Gut and systemic GLP-1 resistance have been previously described in HFD-fed mice, associated with dysglycemia, insulin resistance, increased food intake, and impaired gastric emptying, and attributed to an acquired impairment of the gut-brain axis secondary to intestinal dysbiosis (34)

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Simple Comparison between upcoming Monthly GLP-1s: By Amgen and Pfizer The Monthly Obesity Treatment Race Is Heating Up The next wave of obesity pharmacotherapy may not be about achieving greater efficacy aloneit may also be about achieving it with less frequent dosing

World J Microbiol Biotechnol 32:17

Gutirrez-Rojas I, Lozano D, Nuche-Berenguer B, et al

Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials