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The key treatment is to reverse the catabolic state promptly, thus intravenous glucose, saline and L-carnitine can be injected to urgently stabilize the energy-fragile brain tissue, protect the nerves and prevent striatal necrosis [69, 79, 80]

The search period extended from January 1990 through December 2025 to capture both foundational mechanistic research on testosterone signaling and contemporary clinical trials evaluating GLP-1 receptor agonists and testosterone replacement therapy