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Retatrutide is the first triple-agonist GLP-1/GIP/Glucagon medication in Phase 3 trials, made by Eli Lilly

HeinzerRVatSMarques-VidalPMarti-SolerHAndriesDTobbackNet al

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The phase 2 trial ran for 48 weeks total, and the weight loss curve had not fully plateaued by that point, suggesting continued benefits beyond the trial period

Glucagon-like Peptide-1 Receptor: Mechanisms and Advances in Therapy