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Shungu Once the process starts, it can be hard to tell what is causing what as the mitochondrial and oxidative stress problems feed into each other: In our study of primary mitochondrial disorders (e.g., MELAS), we have found a cortical GSH deficit that seems to be even bigger than in ME/CFS, meaning that mitochondrial dysfunction and oxidative stress co-exist and likely potentiate and sustain each other in such disorders

Serum dipeptidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus

Detka, J

PubMed Central, Knutsen, A

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Healthy aging is defined as the accumulation of time dependent cellular damage which factors include oxidative stress, epigenetic changes, genomic instability, telomere attrition, and dysregulation of cell signaling and inflammatory responses, upon further hit, this natural disruption may become detrimental [53]