Oral bioavailability has not been characterized, and the compound's heptapeptide structure (773.89 Da) makes oral activity less likely than for the smaller Dihexa (504.66 Da), though not impossible given its modified sequence
The investigators in this study did not have direct access to individual patient data for this analysis
Third, several previously published cost-effectiveness studies of obesity pharmacotherapies have successfully applied BMI-only frameworks, producing reliable results that are broadly consistent with multi-biomarker models and policy-relevant in high-income settings (3740)
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