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Some potential side effects of milk thistle include: Stomach problems (such as stomach ache, gas, bloating) Rashes Heartburn Sexual dysfunction (in extreme cases) Headaches Weakness However milk thistle is considered to be safe in doses of up to 420mg per day, so overdosing on it will be quite a difficult thing to do

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Kadenbach B, Ramzan R, Vogt S

These effects of nicotinic acid are exerted by it binding to and activating the hydroxycarboxylic acid receptor 2 (HCA 2 ) which was originally identified as GPR109A