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Discussion Key Study Findings The findings from the NMA support the clinical effectiveness and safety of tirzepatide compared with semaglutide and liraglutide, for multiple clinical outcomes considered in the management of obesity and overweight in patients without T2D, including weight reduction and cardiometabolic risk factors, such as waist circumference, lipids, blood pressure and glycaemic parameters

doi: 10.3390/ijms242216318 59 JiCWeiJZhangLHouXTanJYuanQet al

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This gap in the literature means there is no concrete evidence to confirm whether these two drugs work synergistically to enhance weight loss or improve metabolic health