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Artesunate is a clinically well-tolerated compound that acts synergistically with sorafenib to induce ferroptosis in the HCC cell lines Huh7, SNU-449, and SNU-182 (97)
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Furthermore, these structural modifications drastically extend its half-life from 20 minutes to a staggering 20 to 30 hours
See DOI: 10.1039/c7tx00340d This article summarises the main contributions to the recent Drug Metabolism Group (DMG) meeting held in 2017 60 years of paracetamol: what do we really know?
