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In detail, two short loops of HGF I-K1 (residues 154163

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performed a cross-trial analysis using data from clinical trials of GLP-1RAs (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER-6 [59], and AMPLITUDE-O), SGLT2is (CANVAS and CREDENCE), and finerenone (FIDELIO-DKD and FIGARO-DKD) to estimate the effects of the triple combination therapy of GLP-1RA, SGLT2i, and finerenone using the actuarial method [60]

These were generally mild, in the range of 2-4 beats per minute at lower doses and up to 6-8 BPM at 12mg, and did not produce clinical symptoms in most participants

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