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221 Further, reduced HIF3A methylation and increased HIF3A levels in blood are associated with IR and higher body mass index (BMI) values in T2DM patients

It acts the same way as GLP-1 (a hormone produced in the gut)

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In addition to the above GI AEs, acute pancreatitis was initially reported as an uncommon or rare AE associated with GLP-1 RAs [16, 18, 20, 22, 24, 26, 28]

L., & Moran, L