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A multicenter trial in Alzheimers disease found no benefit on cognitive or functional outcomes while shifting some biomarkers, a smaller trial in healthy older adults reported improved memory and hippocampal connectivity, and the overall assessment is that it is unlikely to help most healthy adults and that the evidence is not conclusive

In a post-hoc subgroup analysis, a 90-day mortality benefit was observed in patients from the USA, raising the possibility that geographic location, timing of treatment, or other factors may modify the therapeutic effect

doi: 10.1021/acschembio.5b00245 69 HeWLinXChenK

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Sterile technique requirements: (1) Alcohol-wipe the rubber stopper on both the peptide vial and bacteriostatic water vial

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