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Vitamin B12 is a water-soluble vitamin

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The most commonly reported side effects are mild and include a temporary increase in hunger (related to its ghrelin receptor activity), mild water retention during the initial weeks, tingling or numbness in the extremities, and occasional headache

The advantages of this experimental design are that entry of the test agent occurs through membrane pores generated by the toxin and is not limited by the presence of appropriate transporters [32]

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