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In summary, fixed ratio combination of GLP-1RA and basal insulin are potentially helpful tools for the treatment of patients with T2DM as a result of its favorable safety and efficacy profile, particularly in patients who are overweight and uncontrolled on OADs or basal insulin
Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]
It should be used with caution in pediatric patients, particularly those younger than 1 month old, due to limited safety data in this population
Take 1 capsule up to twice daily between meals or as directed by your healthcare practitioner
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