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When a compound has no charge, the molecules attract each other and clump together, making dissolution impossible

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These amounts are considered safe because the human body, as a general matter, can safely store from 1,000 to 2,000 times the RDA, without negative consequence (anything more will generally be excreted in urine, per NCBI Bookshelf)

Hydroxocobalamin 20 mg/ml Injection Solution may also interact with certain foods, such as dairy products, alcohol, and caffeine