Retatrutide is a once-weekly weight loss injection that combines the actions of three key metabolic hormones: GLP-1 (helps you feel full and keeps blood sugar in balance) GIP (supports insulin release and helps your body process food for energy) Glucagon (tells your body to burn fat for energy) This triple G mechanism sets it apart from Wegovy, which targets one hormone, and Mounjaro, which targets two
Further studies are needed for elucidation
For example, some patients report a reduction in their libido or less enjoyment in activities due to the blunting of reward
The findings were notable
As with other GLP-1s, gastrointestinal adverse events (nausea, constipation, diarrhea and vomiting) were the most common but were typically mild-to-moderate
However, the American Medical Association, the Endocrine Society, and the Obesity Medicine Association all recommend considering pharmacotherapy for patients with my BMI and comorbidity profile