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Obesity, insulin resistance and type 2 diabetes associated to PCOS will enhance the risk of endometrial cancer in PCOS patients [21, 22]

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Receptor Activity Comparison GLP-1 Receptor Primary Effects: Appetite suppression, insulin secretion, gastric emptying delay Relevance to Bulking: Controls caloric intake, improves nutrient timing GIP Receptor Primary Effects: Enhanced insulin response, fat metabolism, nausea reduction Relevance to Bulking: Better nutrient partitioning, improved tolerance Glucagon Receptor Primary Effects: Increased energy expenditure, fat oxidation, thermogenesis Relevance to Bulking: Preferential fat burning, metabolic rate support The GLP-1 receptor activation provides appetite regulation that many lifters find invaluable during body composition phases