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Urgent research is required to identify synergistic combinations (e.g., FSP1 inhibitors with GPX4 inhibitors, ferroptosis inducers with IDO1/m6A inhibitors, and ferroptosis inducers with immune checkpoint blockade) that can simultaneously bypass multiple resistance pathways across diverse GBM subclones

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In a typical pressure cooker, water can remain a liquid at temperatures as high as 120 o C, and food cooks in as little as one-third the normal time