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For example, multiple studies have demonstrated that metformin can inhibit the growth of thyroid cells and different types of thyroid cancer cells, and metformin therapy has been associated with a decrease in the levels of serum thyroid-stimulating hormone (TSH) (7)

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While studies in mice indicate the potential direct benefits of GLP-1 on the skeletal muscle and bone, human data supporting this hypothesis are absent owing to the absence of GLP-1 receptors in the human skeletal muscle, implying that any effects on muscles are likely indirect [114]

Circulation 145 , 575585 (2022)