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adults who currently take GLP-1 medications for weight loss purposes has risen to 11% in 2026, up significantly from 3% in 2024

However, for long-term effects of the GLP-1-based therapies, more trials data will be required

Response varies

Conclusion Understanding changes in clinical characteristics and treatment patterns over time among new users of SGLT2i or GLP-1 RA in the US as described in this observational study is important to inform and contextualize future studies assessing cardiorenal outcomes for these and additional treatments, including finerenone, for individuals with CKD and type 2 diabetes

Combining two metabolically active agents that influence body composition and hormonal signalling introduces a range of potential safety concerns, even when each drug is used individually within its intended parameters

The inclusion criteria explicitly excluded people with diabetes to isolate weight loss effects in the non-diabetic obese population