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Limiting alcohol and quitting smoking can help improve the effectiveness of this treatment
Impaired individuals exhibit hypomethylation of CpG sites in the CCL11 promoter region, which are then hypermethylated upon supplementation with B12 In impaired individuals, three CpG sites exhibited hypomethylation when compared to the non-impaired group
So, the B12 in the serum is OK, but in the brain, it is low
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