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Clinical trials and recent meta-analyses consistently show tirzepatide delivers the most substantial weight reduction among GLP-1 medications, with average losses of up to 22.5% of body weight

Reviewed by Courtney Floyd, MD, Physician at Ivm Health Disclaimers: This information is for educational purposes only and does not constitute medical advice

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Combine those downsides and endurance performance may actually decline, Kovacs said

For the full Phase 3 safety profile, see our complete retatrutide side effects guide

Fruits and vegetables are the most highly consumed category of food by those taking the drug, with users 29 percentage points more likely to consume them more often than less often. Protein-heavy foods, such as meat and eggs, come in second