Support WBUR How GLP-1s helped a Rhode Island mom get sober after battling alcoholism There's been a lot of buzz over the last year about the use of GLP-1 drugs like Wegovy and Mounjaro all the rage for weight loss to treat cravings for addictive substances, including drugs and alcohol
( GLP-1 RAs recently appearing on the market, in particular liraglutide, semaglutide and tirzepatide (a GIP/GLP-1 RA dual agonist) seek to overcome the problem of the short plasma half-life of native GLP-1 through (i) changing the amino acid sequence of the peptide so that it is no longer broken down by DPP-4, and/or (ii) attaching a long acyl chain to the peptide, thus allowing it to bind to albumin, and avoid rapid elimination via the kidney
Lofton suggests that nutrition guidance be tailored to a patients likes, dislikes, and lifestyle
Lancet 384 (9940): 319-28, 2014
Eat more high-fiber foods, such as fruits, vegetables and whole grains
Specifically, BBR exerted an antioxidant effect by decreasing the generation of cardiac superoxide and gp91 phox expression, and by increasing SOD levels (Yu et al., 2016)