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When used alone, especially in higher doses, the GLP-1s regularly cause loss of muscle and bone (lean body mass)

These findings are relatable to clinical practice, where dosing is often adjusted based on individual needs and clinical judgement, said lead investigator Timothy Garvey, MD, professor of medicine and director of the Diabetes Research Center at the University of Alabama at Birmingham

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May cause nighttime waking

analyses of safety endpoints were based on the safety analysis set (SAS), which included all participants exposed to at least one dose of trial product