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Heart failure symptoms (rare, mostly in those with underlying heart disease): Shortness of breath Swelling in ankles or feet Rapid weight gain

While AOD 9604 targets your metabolism directly, GLP-1s affect appetite and insulin signaling, with no overlap between the two

73% bioavailability via subcutaneous injection

However, this specific combination has not been formally studied

For context, the Mounjaro FDA prescribing information lists injection-site reactions among the documented adverse events across the SURPASS trials at roughly 3-7% uncommon but consistent enough that a methodical approach matters from day one

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