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Macroprolactin is an isoform of PRL with a greater molecular weight but reduced biological activity, occurring in about 20% of cases and associated with asymptomatic hyperprolactinemia

Given that mitochondria constitute the main intracellular source of ROS [61], mitochondrial oxidative damage elicits an upsurge in ROS emission, which may be followed by a vicious cycle of ROS-induced ROS release that drives further oxidative damage [62]

It depends and the answer is changing fast

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MMP Regulation: Balancing Breakdown and Repair Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for degrading extracellular matrix components

There is actually a scenario where split dosing might improve outcomes