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Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases

W.MillerJ.et al (2013)

It decreases COX-2 gene expression, reduces myeloperoxidase activity, and lowers pro-inflammatory cytokines including IL-6 and TNF-alpha

Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)