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An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy, J

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Glutathione is present in all cells and plays a role in cellular metabolism

Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100