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The role of GLP-1 agonists on a persons appetite and caloric intake has become better understood over the years

Sci., 2018 Sikiric et al., BPC 157 and Stable Gastric Pentadecapeptide, Pharmaceuticals, 2024 Lee et al., MOTS-c: mitochondrial-derived peptide, Cell Metabolism, 2015 Brunel University London Epitalon replication study, 2025

This is especially important when using GLP-1 agonists, which can cause lean mass loss alongside fat loss if exercise is not incorporated

it may actually feel more effective (stronger appetite suppression) temporarily but at the cost of increased side effects

However, most previous studies have focused on alcohol, and few have examined whether these medications might also help people who already have a substance use disorder

Some researchers describe a unique quality to the satiety, not just feeling less hungry, but feeling genuinely indifferent to food