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Some patients get paradoxical fatigue or headaches from B12 due to detoxification effects, in which case lower your dose

Vitamin B 12 levels affect the histone modification H3K36me3, which suppresses illegitimate transcription outside of gene promoters

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[125] Storage and excretion [edit] How fast B 12 levels change depends on the balance between how much B 12 is obtained from the diet, how much is secreted and how much is absorbed

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