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Significantly, it has been demonstrated that GLP-1 analogues can suppress NF-B, which is a major activator of IL-6 expression [121]

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Chao CT et al (2020) Astaxanthin counteracts vascular calcification in vitro through an early up-regulation of SOD2 based on a transcriptomic approach

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Concurrently, a significant increase in NADH/NAD + ratio ( P = 0.0002) was observed (Figure 6C), suggesting that the observed metabolic disruptions were a result of oxidative stress, potentially as a compensatory mechanism to sustain energy production and redox homeostasis in the absence of GR

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