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Is it dangerous to stop GLP-1 after taking it long-term

Sitagliptin and Metformin Coadministration in Patients with Type 2 Diabetes Inadequately Controlled on Diet and Exercise A total of 1091 patients with type 2 diabetes and inadequate glycemic control on diet and exercise participated in a 24-week, randomized, double-blind, placebo-controlled factorial study designed to assess the efficacy of sitagliptin and metformin coadministration

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Data demonstrates durable, lifestyle-first solutions for sustainable health outcomes Despite FDA prescription drug labeling recommendations to take GLP-1s in combination with diet and physical activity, before enrolling in the CVS Weight Management program, 70% of members were using a weight management drug without any lifestyle or nutrition support

Analysts from William Blair highlighted concerns that the flexible dosing regimen may signal a challenging tolerability profile