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By: Cami Eastman, RDN, LD on 02/26/2026 As more people in midlife turn to GLP-1 medications for metabolic support, questions are emerging about how these drugs interact with hormone replacement therapy (HRT), what the long-term effects may be for postmenopausal bodies, and what nutritional strategies are most important to protect health

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What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease