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Semaglutide injection, a GLP-1 receptor agonist, is indicated for adults with type 2 diabetes
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359 The inhibition of MELK expression significantly downregulates the expression of the ferroptosis-related genes PTGS2 and SLC39A14 and significantly reduces the expression of the lipid peroxidation marker 4-HNE and the oxidative stress marker MPO, thereby inhibiting macrophage infiltration and M1 polarization, reducing the secretion of proinflammatory factors, and alleviating intestinal tissue damage and intestinal inflammation
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Effects of tirzepatide on cardiac injury and kidney function Treatment with tirzepatide resulted in a significant reduction in myocardial injury reflected by high-sensitivity troponin T as compared with placebo at both 24 and 52 weeks (ETD 24 weeks 9.8% (95% CI 16.0 to 3.3), P = 0.004, 52 weeks 10.4% (95% CI 16.7 to 3.6), P = 0.003), with no significant effect at 12 weeks (Fig