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Conversely, adipocytes from obese mice express twofold lower levels of Gs, a subunit of the GTP-binding protein through which beta-adrenergic receptors stimulate adenylyl cyclase (38)

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To further support the evolutionary role of ADH5 in preventing FA toxicity, we carried out a phylogenetic analysis in eukaryotes looking for genes coding for ADH5-like proteins (Fig

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