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Across subgroups, the weight change was consistently larger for SGLT2i recipients than for GLP1-RA recipients

The most frequently reported adverse effects include: Nausea and vomiting affecting 20-44% of patients (varies by product), particularly during dose escalation Diarrhoea experienced by approximately 18-30% of users depending on the specific medication Constipation occurring in around 19-24% of patients Abdominal pain or discomfort reported by 15-25% of individuals Reduced appetite whilst therapeutically desired, this can sometimes be excessive Dyspepsia and acid reflux affecting a smaller proportion of users These gastrointestinal effects typically emerge during the initial weeks of treatment or following dose increases

The vulnerability of this system to free radicals demand for advanced strategies to combat them