In the phase 2 trial published in the New England Journal of Medicine , participants on the 12 mg dose lost an average of 24.2% of their body weight in just 48 weeks
This may be related to curcumins effect on GLP-1
Cigna said that for employees who had insurance approvals for the drugs, it would cover older, generic weight-loss drugs, including phentermine, diethylpropion, benzphetamine and phendimetrazine, which are less effective than GLP-1s
Of those, 28% (n=25) reported microdosing (taking a smaller amount of medication than prescribed to make it last longer), 23% (n=21) reported combining residual medication to create an additional golden dose and 32% (n=29) reported taking a short break from the medication to save money or make the most of life events, such as weddings or holidays
In a 2025 review, the authors describe this species as occupying an extraordinary niche in the human gut, and a model organism studied for its ability to modulate human health and gut microbiome structure.13 In animal studies, it has slowed the development and progression of diabetes , obesity , and irritable bowel disease .14 In human trials, it has helped participants reduce their BMI and improve their diabetic markers.12 Its effects on obesity and diabetes have been recreated in humans as well
Physician-led virtual clinics are expected to lead Care Model with 51.2% share in 2026
