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Additionally, the possibility of a type II error should be considered in the interpretation of our findings, since the limited number of patients in each arm could have led to the limited effect of L-carnitine on the quality of life

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This concept is powerfully substantiated by a comprehensive meta-analysis encompassing seven major CVOTs, which concluded that the elevated risk of DR progression associated with semaglutide was driven by the magnitude and rapidity of HbA1c reduction, rather than a direct drug effect [86]