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Notably, early studies demonstrated that 1,25(OH)D could inhibit the DNA-binding activity of NF-B in human MRC-5 fibroblasts without preventing the nuclear translocation of its p50 or p65 subunits

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Furthermore, while our work highlighted transcriptional outcomes and intracellular signaling pathways, we did not investigate epigenetic modifications, which are key regulators of developmental transitions and events and could underly the development deficits observed here

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