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They all seriously damage the liver and kidneys

The main sources of ROI are mitochondria, cytochrome P450 enzymes in the hepatocyte, Kupffer cells and neutrophils [12]

Zhang D, Tong X, VanDommelen K, Gupta N, Stamper K, Brady GF, Meng Z, Lin J, Rui L, Omary MB, Yin L (2017) Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity