Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo
Get this wrong and everything downstream falls apart
Risk of bias using Cochrane risk-of-bias tool for randomized trials-Kosibord, 2023
We like it because it addresses many facets important to weight loss, particularly on GLPs
What to track Keep a simple daily log that records bowel movement frequency (how many per day), stool consistency (use the Bristol Stool Scale, aiming for Type 3 or 4), ease of passage (straining versus comfortable), abdominal symptoms (bloating, cramping, gas), water intake (in ounces), fiber intake (approximate grams), exercise (type and duration), and any supplements or laxatives used
This revealed an interaction between the metabolite and mitochondrial trifunctional protein- (MTP), which is known to regulate fatty acid oxidation (FAO) (23)
