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Ann Neurol (2021) 90(2):22738

A big reason for this is that its common to gain back some of the weight youve lost when you stop taking the prescribed medication

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It is noteworthy that a behavioral analysis of Glp1r +/+ , Glp1r +/ and Glp1r/ mouse phenotypes and hippocampal Glp1r gene transfer demonstrated that deficiency of this receptor results in decrements in the acquisition of associative contextual learning which can be improved by hippocampal Glp1r somatic cell gene transfer [45]

(2025b)

With retatrutide and other multi-agonists on the horizon, we may soon see drugs that approach the effectiveness of bariatric surgery without the invasiveness