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Alpha-lipoic acid Increased oxidative stress caused by free radical formation and defects in antioxidant defense related to hyperglycemia is thought to cause endoneurial hypoxia and nerve dysfunction, which contribute to DPN [61]

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norethindrone acetate (NETA), FDA-approved for pain relief with potential androgenic side effects but effective and well-tolerated at low doses for long-term use

Only adult studies were considered, except for occasional pediatric data in high-risk population studies

Carotenoids such as zeaxanthin and -carotene [29] are absorbed in the small intestine

Cagrilintide peptide is used in research and clinical development as a long-acting analogue of amylin, a pancreatic hormone involved in satiety, food intake, glucagon regulation, and gastric emptying