There is no advantage to using the light sensitive forms of cobalamin, such as methylB 12 or adenosylB 12 , instead of the stable cyano or hydroxy forms, which are readily converted in the body into the coenzyme forms, methylB 12 and adenosylB 12
The clinical trial protocol used a gradual dose escalation to minimize GI side effects: Most users inject into the abdominal area, rotating sites with each injection
Because B12 symptoms can look like symptoms of other diseases, diagnosing a B12 deficiency can be challenging
Unapproved peptides do not have established human dosing protocols, so users are essentially guessing at doses based on anecdotal reports
Hydroxocobalamin is also an effective scavenger of nitrogen oxides (nitrogen radicals) responsible for the so-called nitrosative stress involved in the development of many diseases
A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy