pharmaceutical companies manufacturing glp-1 receptor agonist medications How the market could hit $168bn by 2033 Who are the leading innovators

Alam and Czajkowsky, 2022)

In recent works, the study demonstrated that GCH1/ BH4 pathic enzyme dihydrofolate reductase (DHFR) could inhibit ferroptosis by generating BH4, so decrease in DHFR activity reduces BH4 content to enhance lipid peroxidation and sensitizes cells to ferroptosis (Lu et al., 2024), but the detail process is still unknown (Figure 1)

Metformin commonly causes gastrointestinal upset and vitamin B12 depletion with long-term use

extremely unstable metabolites may bind covalently to and inactivate the enzyme that forms them, whereas more stable species may be able to diffuse to a distant site, for example DNA, and initiate changes such as cancer

This results in increased use of health care resources, including the need for hospitalization and the use of nonconventional medication [4]

Acknowledgments This study was supported by the Cooperative Research Program for Agriculture Science & Technology Development (Project No