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[PMC free article: PMC4862197] [PubMed: 26257300] 243

Oral in the treatment of anemia due to insufficient dietary intake of vitamin B 12 in strict vegans : pour the contents of the ampoule into a glass of water

The alanine at position 2 of the peptide was substituted with Aminoisobuturic acid (Aib) to protect the molecule from DDP-IV inactivation, and a lactam bridge was introduced between amino acids 16 and 20 to stabilize the secondary structure to ensure glucagon receptor potency

The functionality of the differentiated HLCs was rigorously assessed using several in vitro assays

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Additional areas of active investigation include the peptide's potential effects on bone healing, where studies have reported accelerated fracture consolidation in animal models