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According to a 2024 article by the Columbia University Department of Psychiatry, semaglutides 2021 FDA approval came with wide recognition for its medical benefits and its notable side effect of weight loss. What resulted from that was a surge in its off-label use as a weight-loss aid, propelling the drug into the spotlight far beyond its original intent. Then, also in 2021, the FDA approved Wegovy for individuals who are obese or overweight with additional health challenges. Columbia University also notes the ethical concerns of drugs like Ozempic and Wegovy, particularly in their pricing

Animal studies have shown fetal growth abnormalities and skeletal malformations at clinically relevant doses, though these findings don't always predict human outcomes

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The initial adjustment phase typically lasts 3 to 7 days, though some people experience symptoms for up to 2 weeks

USA 118 , e2019768118 (2021)

Zhang, Xi et al