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While the passive technique focuses on drug and vehicle interaction and optimization to affect the stratum corneum structure, the active approach utilizes external energy to facilitate the transportation of drugs through the skin or by physically disrupting the outermost layer of the skin, known as the stratum corneum [230, 231]

Another study confirmed the effectiveness following sudden acute hearing loss: In this study, supplementation with coenzyme Q10 in combination with steroid-based (cortisone) treatment led to a clear improvement in the ability to understand speech compared to the results of a standard course of therapy